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. 2022 Mar 24;127(2):202–210. doi: 10.1038/s41416-022-01784-9

Fig. 5. H3K23 acetylation binds with TRIM24 to mediate SOX2 expression.

Fig. 5

a Immunoprecipitation (IP) measure the effects of KAT6A overexpression or knockdown on H3K23ac association with TRIM24. b ChIP-qPCR assays of the binding of TRIM24 and H3K23ac with the SOX2 promoter. c Overexpression of Flag-TRIM24 wild-type but not the binding mutant of TRIM24 with H3K23ac, F979A/N980A, promoted SOX2 expression. d Effects of overexpression of Flag-TRIM24 wild-type or F979A/N980A mutant on the binding of TRIM24 and H3K23ac with SOX2 promoter. Effects of overexpression of Flag-TRIM24 wild-type or F979A/N980A mutant on cell viability e, proliferation f and colony formation g in Hep3B cells. *P < 0.05.