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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Int J Tuberc Lung Dis. 2022 Feb 1;26(2):85–88. doi: 10.5588/ijtld.21.0736

Table.

Recommended therapies and dosages for TB preventive therapies, adapted from17

Regimen Dose by weight band

1 month of daily INH + RPT (1HP): 28 doses Age ≥13 years (regardless of weight band)
INH 300 mg/day
RPT 600 mg/day
3 months of weekly INH + RPT (3HP): 12 doses Age 2–14 years
 Medicines/formulations 10–15 kg 16–23 kg 24–30 kg 31–34 kg >34 kg
 INH 100 mg* 3 5 6 7 7
 RPT 150 mg 2 3 4 5 5
Age >14 years
 Medicines/formulations 30–35 kg 36–45 kg 46–55 kg 56–70 kg >70 kg
 INH 300 mg 3 3 3 3 3
 RPT 150 mg 6 6 6 6 6
*300 mg can be used to reduce the pill burden
3 months of daily INH + RIF (3HR): ∼90 doses INH:
 Age ≥10 years: 5 mg/kg/day
 Age <10 years: 10 mg/kg/day (range 7–15 mg)
RIF:
 Age ≥10 years: 10 mg/kg/day
 Age <10 years: 15 mg/kg/day (range 10–20 mg)
4 months of daily RIF (4R): ∼120 doses Age ≥10 years: 10 mg/kg/day
Age <10 years: 15 mg/kg/day (range 10–20 mg)
6 or 9 months of daily INH therapy (6H, 9H): ∼180 or 270 doses Age ≥10 years: 5 mg/kg/day
Age <10 years: 10 mg/kg/day (range 7–15 mg)

INH = isoniazid; RPT = rifapentine; RIF = rifampicin.