Table.
Regimen | Dose by weight band | |||||
---|---|---|---|---|---|---|
| ||||||
1 month of daily INH + RPT (1HP): 28 doses | Age ≥13 years (regardless of weight band) | |||||
INH 300 mg/day | ||||||
RPT 600 mg/day | ||||||
3 months of weekly INH + RPT (3HP): 12 doses | Age 2–14 years | |||||
Medicines/formulations | 10–15 kg | 16–23 kg | 24–30 kg | 31–34 kg | >34 kg | |
INH 100 mg* | 3 | 5 | 6 | 7 | 7 | |
RPT 150 mg | 2 | 3 | 4 | 5 | 5 | |
Age >14 years | ||||||
Medicines/formulations | 30–35 kg | 36–45 kg | 46–55 kg | 56–70 kg | >70 kg | |
INH 300 mg | 3 | 3 | 3 | 3 | 3 | |
RPT 150 mg | 6 | 6 | 6 | 6 | 6 | |
*300 mg can be used to reduce the pill burden | ||||||
3 months of daily INH + RIF (3HR): ∼90 doses | INH: | |||||
Age ≥10 years: 5 mg/kg/day | ||||||
Age <10 years: 10 mg/kg/day (range 7–15 mg) | ||||||
RIF: | ||||||
Age ≥10 years: 10 mg/kg/day | ||||||
Age <10 years: 15 mg/kg/day (range 10–20 mg) | ||||||
4 months of daily RIF (4R): ∼120 doses | Age ≥10 years: 10 mg/kg/day | |||||
Age <10 years: 15 mg/kg/day (range 10–20 mg) | ||||||
6 or 9 months of daily INH therapy (6H, 9H): ∼180 or 270 doses | Age ≥10 years: 5 mg/kg/day | |||||
Age <10 years: 10 mg/kg/day (range 7–15 mg) |
INH = isoniazid; RPT = rifapentine; RIF = rifampicin.