Figure 5.

CCC-specific IgG responses are detected in all individuals and sustained over time

(A) Plasma IgG titers, measured by the AUC, to the spike receptor binding domain (RBD) protein of the CCC viruses (HcoV-229E, HcoV-NL63, HcoV-HKU1, and HcoV-OC43) are shown for first time point of the longitudinal cohort (n = 32). Geometric mean titers with SD are indicated.

(B) Graphs show individual CCC antibody responses plotted for all time points of the longitudinal series and connected with lines for each subject (n = 32). The red line represents the median fitted curve from a nonlinear mixed effects model of longitudinal responses among those with a positive response at ≥1 time point, with 95% CI shown in blue dotted lines. t_1/2 calculated based on linear mixed effects model using R package nlme (Cohen et al., 2021); t_1/2 is shown as the median half-life estimated from the median slope with the associated 95% CI indicated.