Table 3.
Comparison of example DTI region of interest values within clinical cohorts at baseline and at 6 or 12-month follow-up.
| DTI Regions of Interest | Example ROI | Cohort | Time-point | n | FA | % change | p- value | MD (10−4 mm2/s) | % change | p- value | L1 (10−4 mm2/s) | % change | p- value | L 2and 3 (10−4 mm2/s) | % change | p- value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Midline right-left tracts adjacent to ventricles e.g., BCC, GCC | BCC | mTBI | 0 M | 24 | 0.520 ± 0.065 | −4.3 | 0.022 | 9.162 ± 1.07 | −2.9 | 0.246 | 15.280 ± 2.21 | −4.6 | 0.137 | 6.104 ± 0.70 | −0.8 | 0.681 |
| 6 M | 24 | 0.498 ± 0.057 | 8.898 ± 0.32 | 14.583 ± 0.87 | 6.055 ± 0.45 | |||||||||||
| NPH Pre-op | 0 M | 16 | 0.478 ± 0.097 | +2.3 | 0.601 | 9.348 ± 1.45 | −0.2 | 0.954 | 14.430 ± 1.50 | +0.1 | 0.959 | 6.807 ± 1.67 | +5.5 | 0.486 | ||
| NPH Post-op | 6 M | 16 | 0.490 ± 0.104 | 9.329 ± 1.26 | 14.448 ± 1.22 | 7.181 ± 2.30 | ||||||||||
| AD | 0 M | 27 | 0.355 ± 0.053 | −6.5 | 0.006 | 14.202 ± 1.58 | +7.8 | 0.014 | 19.434 ± 1.38 | +5.4 | 0.010 | 11.363 ± 1.83 | +12.1 | 0.013 | ||
| 12 M | 27 | 0.332 ± 0.075 | 15.315 ± 3.30 | 20.480 ± 2.65 | 12.733 ± 3.65 | |||||||||||
| Lateral to ventricles (long or short) anterior-posterior e.g., ILF, ATR tracts, PTR, CGC | ILF/PTR | mTBI | 0 M | 24 | 0.423 ± 0.077 | −4.1 | 0.133 | 8.953 ± 1.08 | −1.4 | 0.604 | 13.329 ± 2.77 | −3.4 | 0.438 | 6.765 ± 0.45 | +0.5 | 0.743 |
| 6 M | 24 | 0.405 ± 0.051 | 8.824 ± 0.32 | 12.880 ± 0.81 | 6.796 ± 0.41 | |||||||||||
| NPH Pre-op | 0 M | 16 | 0.545 ± 0.051 | −11.9 | 0.002 | 7.807 ± 0.69 | −0.1 | 0.981 | 13.040 ± 1.38 | −6.6 | 0.037 | 5.191 ± 0.55 | +14.0 | 0.030 | ||
| NPH Post-op | 6 M | 16 | 0.480 ± 0.074 | 7.802 ± 0.62 | 12.184 ± 1.20 | 5.919 ± 1.24 | ||||||||||
| AD | 0 M | 27 | 0.355 ± 0.028 | −2.9 | <0.001 | 10.054 ± 0.86 | +2.4 | 0.009 | 13.832 ± 0.97 | +1.9 | 0.127 | 8.055 ± 0.98 | +4.2 | 0.054 | ||
| 12 M | 27 | 0.345 ± 0.031 | 10.300 ± 1.08 | 14.095 ± 1.10 | 8.400 ± 1.09 | |||||||||||
| Fronto-temporal, multi-directional tractse.g., IFO, UNC | IFO/ UNC | mTBI | 0 M | 24 | 0.444 ± 0.056 | −5.5 | 0.032 | 9.491 ± 1.09 | −2.6 | 0.306 | 14.473 ± 2.41 | −5.0 | 0.180 | 7.000 ± 0.56 | −0.2 | 0.914 |
| 6 M | 24 | 0.420 ± 0.034 | 9.241 ± 0.34 | 13.749 ± 0.53 | 6.988 ± 0.41 | |||||||||||
| NPH Pre-op | 0 M | 16 | 0.403 ± 0.059 | −6.5 | 0.032 | 7.140 ± 0.42 | −0.9 | 0.567 | 10.402 ± 0.75 | −3.1 | 0.073 | 5.358 ± 0.74 | +9.6 | 0.148 | ||
| NPH Post-op | 6 M | 16 | 0.377 ± 0.054 | 7.072 ± 0.47 | 10.083 ± 0.73 | 5.871 ± 1.10 | ||||||||||
| AD | 0 M | 27 | 0.274 ± 0.038 | −8.3 | 0.013 | 10.404 ± 1.33 | +2.5 | 0.118 | 12.810 ± 1.40 | +3.5 | 0.010 | 8.933 ± 1.39 | +4.9 | 0.018 | ||
| 12 M | 27 | 0.251 ± 0.031 | 10.664 ± 1.41 | 13.257 ± 1.39 | 9.367 ± 1.44 | |||||||||||
| Remote functional tracts distorted by ventricles, superior-inferior e.g., PLIC, CST | PLIC | mTBI | 0 M | 24 | 0.618 ± 0.046 | −1.6 | 0.234 | 8.644 ± 1.12 | −2.8 | 0.314 | 15.563 ± 1.99 | −3.1 | 0.266 | 5.183 ± 0.76 | −2.4 | 0.424 |
| 6 M | 24 | 0.609 ± 0.032 | 8.403 ± 0.24 | 15.087 ± 0.45 | 5.061 ± 0.34 | |||||||||||
| NPH Pre-op | 0 M | 16 | 0.751 ± 0.034 | −11.5 | <0.001 | 5.879 ± 0.44 | +1.0 | 0.559 | 12.377 ± 1.01 | −8.3 | <0.001 | 3.255 ± 2.01 | +21.8 | 0.390 | ||
| NPH Post-op | 6 M | 16 | 0.665 ± 0.077 | 5.937 ± 0.54 | 11.350 ± 0.99 | 3.964 ± 2.13 | ||||||||||
| AD | 0 M | 27 | 0.518 ± 0.032 | −0.3 | 0.752 | 7.524 ± 0.45 | +0.6 | 0.469 | 12.437 ± 0.73 | +0.2 | 0.800 | 5.075 ± 0.49 | +0.9 | 0.542 | ||
| 12 M | 27 | 0.517 ± 0.035 | 7.568 ± 0.45 | 12.464 ± 0.56 | 5.120 ± 0.49 |
ATR, anterior thalamic radiation; BCC, body of the corpus callosum; CGC, cingulum; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; GCC, genu of the corpus callosum; IFO, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; L1, axial diffusivity, L2 and 3, radial diffusivity; MD, mean diffusivity; PLIC, posterior limb of the internal capsule; PTR, posterior thalamic radiation; UNC, uncinate fasciculus. The bold values represent significant p values at α <0.05.