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. 2022 Jul 6;9:888411. doi: 10.3389/fvets.2022.888411

Table 4.

Effect of clinical stage, surgical margins, inflammatory indices (NRL, PLR, MLR, SII, and CRP/ALB ratio), albumin, LDH, and frequency of circulating cells (lymphocytes CD4, CD8, CD4/CD8 ratio, Tregs, (M)-MDSCs, and (PMN)-MDSCs) on the PFS and OS of 25 canine patients with oral melanoma.

Variable PFSa HR (95% CI) p–value OSa HR (95% CI) p–value
All dogs 68 115
Stage
II 181 1 0.010* 265 1 0.015*
III 40 4.0 (1.3–12.6) 0.017* 101 3.1 (0.9–10.1) 0.054*
IV 38 10.2 (2.1–50.5) 0.004* 68 12.2 (2.2–67.5) 0.004*
CRP/ALB ratio 1.1 (1.0–1.1) 0.017* 1.0 (1.0–1.1) 0.023*
Treg 1.6 (1.2–2.1) 0.001* 1.6 (1.2–2.1) 0.001*

aMedian in days; *Statistical significance.

95%CI, 95% confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression-free survival; CRP/ALB ratio, C-reactive protein/Albumin ratio; Treg, T regulatory cells.