Canakinumab

Organ systems affected	Adverse event(s)		Refs.
Systemic	a) Immediate-type adverse reactions	Fever	(36, 37, 82, 83, 87)
	b) Infection	Bronchitis, cellulitis, cutaneous abscess, gastrointestinal infection, herpes infection, influenza virus infection, peritonitis, pneumonia, septic shock, upper respiratory tract infection, urinary tract infection, viral infection	(31, 32, 36, 37, 41–43, 72, 76, 82, 83, 87)
	c) Neoplasm
Cardiovascular	Deep vein thrombosis, hypotension, hypertension, pericarditis, pulmonary hypertension		(19, 31, 37, 42, 43, 76, 82, 83, 87)
Gastrointestinal and hepatic	Abdominal pain, diarrhea, elevated liver enzymes, gastroenteritis, hepatitis, hepatobiliary disorder, nausea, weight gain		(19, 31, 36, 37, 42, 43, 72, 76, 82, 83, 87)
Hematologic events	Anemia, neutropenia, macrophage activation syndrome, thrombocytopenia		(36, 37, 83, 87)
Musculoskeletal	Arthralgia, joint pain, muscle spasm, musculoskeletal pain		(19, 31, 37, 42, 43, 76, 82, 87)
Nervous system (including eyes)	Fatigue, headache, vertigo, increased intraocular pressure, seizure, paraesthesia		(31, 32, 37, 42, 56, 82, 83, 87, 89)
Renal and urogenital	Hypokalemia		(37, 83)
Upper and lower airways	Asthma, cough, nasopharyngitis, rhinitis, sinus congestion		(31, 42, 43, 76, 82, 87)
Skin	Injection site reaction, pyoderma gangrenosum, rash, rosacea		(32, 36, 37, 42, 43, 56, 72, 76, 83, 87)