Rilonacept

Organ systems affected	Adverse event(s)		Refs.
Systemic	a) Immediate-type adverse reactions	Allergic reaction, fever	(34, 58, 84, 85)
	b) Infection	Liver abscess, otitis media, pneumonia, skin infection, upper respiratory tract infection, urinary tract infection, vaginal infection, viral gastroenteritis	(33, 34, 38, 44–47, 58, 77, 84, 85, 89)
	c) Neoplasm	Actinic keratosis, basal cell carcinoma, prostate cancer, squamous cell carcinoma	(45, 58, 77)
Cardiovascular	Carotid artery dissection, palpitation, pericarditis		(58, 85)
Gastrointestinal and hepatic	Abdominal pain, diarrhea, dyspepsia, ileus, liver function abnormalities, nausea		(33, 45, 47, 58, 85, 89)
Hematologic events	Eosinophilia, neutropenia, macrophage activation syndrome, pancytopenia		(84)
Musculoskeletal	Arthralgia, gout exacerbation, joint pain, musculoskeletal pain		(33, 44, 45, 77, 84, 85, 89)
Nervous system (including eyes)	Depression, dizziness, fatigue, headache, hordeolum, hypoesthesia, stroke		(33, 44, 46–48, 58, 85)
Renal and urogenital	Altered renal function		(45)
Upper and lower airways	Cough, pulmonary fibrosis, rhinorrhea		(33, 34, 44, 84, 85, 89)
Skin	Angioedema, eczema, erythema, hair loss, hyperhidrosis, injection site reaction, plantar wart, rash		(33, 34, 38, 44–47, 58, 77, 84, 89)