Figure 1.

MDP plots representing the change in gene expression perturbation in TB patients categorized based on TB treatment outcome. Full blood transcriptomes from TB patients who had a good or poor TB treatment outcome were determined by (a) RNA-Seq and by (b) dcRT-MLPA. The extent of overall difference in gene expression, relative to the median of expression at diagnosis in those who had a good TB treatment outcome, was calculated for individual patients at the timepoints shown. The bars and whiskers show the median and data within the Q₁-1·5 x inter quartile range (IQR) and Q₃+1·5 x IQR interval. Differences were significant by Mann-Whitney U-test with Benjamini-Hochberg correction for multiple testing. * P < 0·05, ** P < 0·01, *** P < 0·001, **** P < 0·0001.