Figure 3.

DEA of all TB patients from the pooled (South African and Indonesian) cohorts categorized based on TB treatment outcome compared to their gene expression levels at diagnosis. (a) Volcano plots representing DEGs regulated during TB treatment of TB patients who had a good TB treatment outcome (left panel) or a poor TB treatment outcome (right panel). The y-axis scales of the plots are harmonized per TB treatment outcome. -log₁₀-transformed P-values are plotted against log₂ FC. Genes with P < 0·05 and log₂ FC<-0·6 or >0·6 were labelled as DEGs. (b) Heatmaps displaying log₂ FC of the DEGs and corresponding gene modules. The saturation of color represents the magnitude of differential expression. Differences were significant by means of linear mixed models. * P < 0·05, ** P < 0·01, *** P < 0·001, **** P < 0·0001.