Table 3.
dcRT-MLPA Gene signatures Good versus Poor obtained by pooling the study groups and the cohorts.
| Diagnosis signature | |
|---|---|
| Gene | Module |
| GBP1 | IFN signaling genes |
| FCGR1A | IFN signaling genes |
| STAT1 | IFN signaling genes |
| IFITM3 | IFN signaling genes |
| BCL2 | Apoptosis - Survival |
| CCL4 | Treg associated genes |
| TLR9 | Pattern recognition receptors |
| CD274 | IFN signaling genes |
| Week two signature | |
|---|---|
| Gene | Module |
| GBP5 | IFN signaling genes |
| INDO | IFN signaling genes |
| GBP1 | IFN signaling genes |
| BMP6 | Cell growth - proliferation |
| CXCL9 | Chemokines |
| GATA3 | Th2 associated genes |
| FCGR1A | IFN signaling genes |
| MMP9 | Inflammation |
| PTPRCv1 | T cell subset markers |
| SPP1 | Inflammation |
| CD3E | T cell subset markers |
| ASAP1 | Small GTPases - (Rho) GTPase activating proteins |
| IL5 | Th2 associated genes |
| TNFRSF1B | Apoptosis - Survival |
| NLRP2 | Inflammasome components |
| MRC1 | Pattern recognition receptors |
| NLRP6 | Inflammasome components |
| IL22RA1 | Th17 associated genes |
| VEGF | Cell growth - proliferation |
| KIF1B | Intracellular transport |
| CCL19 | Chemokines |
| CD209 | Pattern recognition receptors |
| Month 2 Signature | |
|---|---|
| Gene | Module |
| BLR1 | G protein-coupled receptors |
| BMP6 | Cell growth - proliferation |
| CCL13 | Chemokines |
| GBP1 | IFN signaling genes |
| GBP2 | IFN signaling genes |
| GBP5 | IFN signaling genes |
| IFI16 | IFN signaling genes |
| IL9 | Th9 associated genes |
| INDO | IFN signaling genes |
| MMP9 | Inflammation |
| NOD2 | Pattern recognition receptors |
| OAS3 | IFN signaling genes |
| PTPRCv2 | T cell subset markers |
| TAP1 | IFN signaling genes |
Genes that appeared in more than one gene signature (diagnosis, week two or month two) are shown in bold. Gene signatures were obtained by down-sampling the majority class (good TB treatment outcome).