Table 3.
Median (min-max range) pharmacokinetic parameters of different doses of NAB-PTX following PIPAC administration.
| Tmax (h) |
Cmax (ng/mL) |
AUC0-24h (h*ng/mL) |
Vd (L) |
CL (L/h) |
T1/2 (h) |
|
|---|---|---|---|---|---|---|
| 35 mg/m² (n = 2, 5 PIPACs) | 4 (1.5-4) | 57.84 (38.54-77.13) | 541.58 (497.66-733.93) | 1074.4 (883.5-1933.9) | 84.44 (73.07-90.29) | 8.82 (7.25-18.34) |
| 70 mg/m² (n = 2, 6 PIPACs) | 3 (2-4) | 128.95 (101.81-218.91) | 910.23 (727.07-1381.78) | 1141.7 (350.5-1460.2) | 111.77 (77.48-154.41) | 7.08 (2.30-10.65) |
| 90 mg/m² (n = 3, 9 PIPACs) | 4 (2-4) | 106.02 (78.50-114.71) | 806.21 (710.45-936.25) | 2216.5 (1421.6-2851.8) | 190.90 (151.89-239.69) | 8.05 (5.72-12.56) |
| 112.5 mg/m² (n = 3, 9 PIPACs) | 4 (1.5-4) | 151.18 (94.55-220.75) | 1747.44 (1162.14-2448.41) | 961.4 (659.5-1968.6) | 85.20 (63.75-137.69) | 7.82 (6.74-16.02) |
| 140 mg/m² (n = 10, 29 PIPACs) | 4 (2-12) | 158.4 (4.33-415.87) | 1904.83 (82.17-3879.67) | 1330.9 (561.3-42405.0) | 112.02 (49.17-934.73) | 8.23 (4.01-31.44) |
Tmax = time to reach maximum concentration; Cmax = maximum concentration; AUC0-24h = area under the curve, Vd = volume of distribution, CL = clearance; T1/2 = elimination half-life.