Table 3.

MICs of novel fluoroquinolones to systemic (non-keratitis) isolates

Organism	Fluoroquinolone	MIC90	Range(mg/L)	Reference
S. pneumoniae	Avarofloxacin	0.25	0.06–0.5	79
	Delafloxacin	0.015	≤0.004–0.12	95
	Finafloxacin	2	0.5–4	96
	Zabofloxacin	0.03	0.015–0.06	99
	Nemonoxacin	0.06	0.03–1	100
S. aureus, MRSA FQ - resistant	Avarofloxacin	0.25	0.015–2	79
	Delafloxacin	0.5	0.25–1	101
	Finafloxacin	16	0.25–32	96
	Zabofloxacin	32	0.016–64	102
	Nemonoxacin	1	0.5–1	100
S. aureus, MRSA FQ-susceptible	Avarofloxacin	0.008	0.008–0.015	90
	Delafloxacin	0.03	0.008–0.03	101
	Finafloxacin	0.25	0.125–0.25	96
	Zabofloxacin	0.125	0.016–1	102
	Nemonoxacin	0.06	≤0.008–0.12	103
E. coli	Avarofloxacin	16	1–16	79
	Delafloxacin	4	<0.004 to>4	62
	Finafloxacin	256	16 ->256	96
	Zabofloxacin	1	0.015–64	99
P. aeruginosa	Avarofloxacin	2	0.5–4	79
	Delafloxacin	>4	0.015->4	62
	Finafloxacin	16	1–32	96
	Zabofloxacin	>64	<0.008–>64	99
	Nemonoxacin	32	0.12–32	103
H. influenzae	Avarofloxacin	0.015	0.008–0.015	79
	Delafloxacin	0.004	≤0.001–0.25	95
	Finafloxacin	≤0.004–0.06	0.03	96
	Zabofloxacin	0.008	<0.008–0.008	99
	Nemonoxacin	NA	≤0.008–0.06	104

FQ—resistant indicates resistance to ciprofloxacin. The ranges for some of the FQs, for example, zabofloxacin, are large and this may partly reflect the clinical isolates and number of isolates against which they were tested.

Adapted from ⁶³

FQ, fluoroquinolones; MICs, minimum inhibitory concentrations; MRSA, methicillin resistant S. aureus; NA, not available.