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. 2022 Jul 20;481(3):351–366. doi: 10.1007/s00428-022-03344-1

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Diagnostic algorithm for liquid biopsy use in advanced/metastatic NSCLC (updated IASLC consensus statement) [34]. Figure reproduced from [34], J Thorac Oncol, Vol. 16, Rolfo C, et al., Liquid Biopsy for Advanced NSCLC: A Consensus Statement From the International Association for the Study of Lung Cancer, pages 1647–1622. Copyright (2021), with permission from J Thorac Oncol. Published by Elsevier Ltd. All rights reserved. Sequential approach: tissue followed by cfDNA complementary approach, concurrent tissue and cfDNA, plasma first approach, cfDNA first. cfDNA cell-free DNA, IASLC International Association for the Study of Lung Cancer, NSCLC non-small cell lung cancer