Table 2.
Multivariable analysis for overall survival of 143 patients with glioblastoma, IDH-wildtype (16 patients excluded due to missing data) by Cox proportional hazards model. The effect of the treatment regimen is adjusted for significant covariables (univariable analysis p <0.10) excluding histological factors.
| Variables | n | HR (95%CI) | p valuea |
|---|---|---|---|
| Treatment regimen | 0.57 | ||
| Temozolomide and radiotherapy vs. radiotherapy only | 101 vs. 42 | 0.89 (0.60–1.33) | |
| Age group | 0.009 | ||
| ≥50 years vs. <50 years | 101 vs. 42 | 1.75 (1.15–2.67) | |
| MMSE score | 0.22 | ||
| ≤26 vs. 27–30 | 27 vs. 116 | 1.33 (0.84–2.38) | |
| Type of surgery | 0.095 | ||
| Biopsy vs. resection | 42 vs. 101 | 1.40 (0.94–2.07) | |
| Corticosteroid use | 0.019 | ||
| Stable/decreasing dose vs. no use | 47 vs. 96 | 1.61 (1.08–2.38) | |
| MGMT promoter | 0.14 | ||
| Methylated vs. unmethylated | 50 vs. 93 | 0.75 (0.52–1.10) |
a
Wald test. HR = hazard ratio. CI = confidence interval. MMSE = mini-mental state examination.