Table 1.
Effect sizes of anesthesia-induced tau hyperphosphorylation immediately and 24 h after anesthesia
| Soluble cortex | Soluble hippocampus | |||||
|---|---|---|---|---|---|---|
| RZ3 | CP13 | PHF1 | RZ3 | CP13 | PHF1 | |
| Effect size (95% CI) | Effect size (95% CI) | |||||
| Immediately after AN | ||||||
|
COMTKO/P301L (n per group = 8, 10) |
0.060 (− 0.87,0.99) |
3.57* (2.08,5.07) |
1.52* (0.46,2.57) |
0.48 (− 0.46,1.42) |
1.65* (0.57,2.72) |
2.85* (1.53,4.16) |
|
P301L (n per group = 8, 8/7) |
1.12* (0.06,2.17) |
3.17* (1.65,4.69) |
1.01 (− 0.03,2.06) |
0.98 (− 0.09,2.06) |
1.38* (0.25,2.51) |
2.26* (0.97,3.56) |
| 24 h after AN | ||||||
|
COMTKO/P301L (n per group = 8, 8) |
− 2.07* (− 3.28,− 0.86) |
− 0.38 (− 1.37,0.61) |
− 1.20* (− 2.27,− 0.14) |
− 0.30 (− 1.28,0.69) |
− 0.15 (− 1.13,0.83) |
− 0.10 (− 1.08,0.89) |
|
P301L (n per group = 8, 8/7) |
− 1.00 (− 2.04,0.04) |
1.11* (0.05,2.16) |
− 0.07 (− 1.05,0.92) |
− 0.08 (− 1.09,0.94) |
− 0.15 (− 1.16,0.87) |
0.52 (− 0.48,1.52) |
The level of hyperphosphorylation, as quantified by ELISA, in the mice either immediately or 24 h after anesthesia was compared to that of the control mice. Hedges’ g was calculated with 95% confidence intervals to estimate the effect size of the difference between two groups. Asterisk indicates that the 95% confidence interval does not include zero. Sample size for the control group is listed first in the first column. AN anesthesia, CI confidence interval