Table 2.
Effect sizes of anesthesia-induced tau hyperphosphorylation one and three months after anesthesia
| Insoluble cortex | |||
|---|---|---|---|
| RZ3 | CP13 | PHF1 | |
| Effect size (95% CI) | |||
| One month after AN | |||
|
COMTKO/P301L at 5 mo (n per group = 12) |
0.22 (− 0.58, 1.02) |
0.09 (− 0.71, 0.89) |
0.46 (− 0.35, 1.27) |
| Three months after AN | |||
|
COMTKO/P301L at 7 mo (n per group = 17, 13) |
2.07* (1.18, 2.96) |
2.03* (1.14, 2.91) |
1.69* (0.85, 2.53) |
The level of hyperphosphorylation, as quantified by ELISA, in the mice either one or three months after anesthesia was compared to that of the control mice. Hedges’ g was calculated with 95% confidence intervals to estimate the effect size of the difference between two groups. Asterisk indicates that the 95% confidence interval does not include zero. Sample size for the control group is listed first in the first column. AN anesthesia, CI confidence interval, mo months old