Table 7.
Adipogenesis
| Active components | Biomaterials | Experimental model | Efficacy | References |
|---|---|---|---|---|
| Icaritin | PLGA/TCP | Rabbit BMSC, 3T3-L1, 10−6 M; SAON emu proximal femur defect model; SAON rabbit distal femur defect model | Down-regulating C/EBP, aP2, PPAR-γ and lipid droplet | [156] |
| PLGA/TCP | BMSC, BMC 0.052: 100 (powder weight to solution volume); rat calvarial defect model | Down-regulating PPAR-γ2 | [145] | |
| Gel hydrogels | hMSC, 100, 200 nM; SAON rat femoral head defect | Down-regulating PPAR-γ and c-Src | [157] | |
| Curcumin | Silk hydrogel | hBMSC; 12.5 µM | Down-regulating PPAR-γ, LPL, FABp4 and Glut4 | [158] |
| Epigallocatechin gallate | PLLA | ADSCs, Raw 264.7, 1 mg/mL; mouse calvarial defect | Down-regulating LPL and PPAR-γ | [113] |