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. 2022 Jul 20;21:149. doi: 10.1186/s12943-022-01619-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Downregulation of circGPR137B is associated with poor survival in patients with HCC. A CircRNA profiling analysis of the differentially-expressed circRNAs between HCC and adjacent normal tissues. B Heatmap analysis of 96 upregulated circRNAs and 51 downregulated circRNAs in HCC according to the restrictive conditions (P < 0.05 and FC > 1.5). C Volcano plot of a new substantially downregulated hsa_circ_0017114 (circGPR137B) in HCC tissues. D CircRNA profiling analysis of the expression of circGPR137B in 3 paired HCC tissues. E RT-qPCR analysis of the expression of circGPR137B in 5 paired HCC tissues. F, G FISH validation of the expression of circGPR137B in 87 paired HCC tissues. Blue color: DAPI; Green color: circGPR137B. H, I Kaplan–Meier analysis of the association of circGPR137B high or low expression with overall survival in HCC and early stage ones