Fig. 3.

MGMT expression assessed by RNAseq (TPM values). Overall survival (OS) (A) and first‐line progression‐free survival (B) represented through Kaplan–Meier curves according to MGMT expression in the MASTER BTC cohort. Patients with lower MGMT mRNA expression (blue) showed significantly poorer OS as compared with patients with high MGMT expression (red) (A). MGMT mRNA expression had no significant impact on progression‐free survival of of patients treated with first‐line systemic treatment (B). Dotted lines indicate the median survival time. MGMT, O ⁶‐methylguanine‐DNA methyltransferase; TPM, transcripts per kilobase million; RNAseq, RNA sequence; MASTER BTC Molecularly Aided Stratification For Tumor Eradication Research on Biliary Tract Cancers. [Colour figure can be viewed at wileyonlinelibrary.com]