TABLE 3.
Resting pulmonary function (pulmonary function test, PFT) and submaximal and peak exercise data for Long-CoV, no-longer symptomatic (ns)-CoV and Controls.
| Self-reported symptom groupings | Long-CoV | Ns-CoV | Con | ||
|---|---|---|---|---|---|
| PFT | FVC | l | 4.25 (0.76) | 4.19 (1.07) | 4.36 (0.84) |
| % pred | 104 (11) | 99 (16) | 105 (8) | ||
| n < LLN | 0 | 1 | 0 | ||
| FEV1 | l | 3.29 (0.63) | 3.29 (0.72) | 3.49 (0.70) | |
| % pred | 98 (11) | 94 (13) | 102 (9) | ||
| n < LLN | 1 | 1 | 0 | ||
| FEV1:FVC | ratio | 0.78 (0.08) | 0.79 (0.08) | 0.80 (0.05) | |
| % pred | 94 (8) | 96 (9) | 97 (6) | ||
| n < LLN | 4 | 2 | 1 | ||
| IC | l | 2.93 (0.55) | 2.73 (0.74) | 3.10 (0.78) | |
| % pred | 99 (13) | 91 (18) | 104 (15) | ||
| n < LLN | 0 | 3 | 0 | ||
| TLC | l | 5.81 (1.02) | 5.67 (1.25) | 5.85 (1.06) | |
| % pred | 100 (11) | 95 (14) | 99 (8) | ||
| n < LLN | 1 | 1 | 0 | ||
| RV | l | 1.48 (0.43) | 1.45 (0.37) | 1.44 (0.38) | |
| % pred | 102 (23) | 104 (29) | 100 (26) | ||
| DLCO | ml/min/mmHg | 25.4 (5.2) | 26.8 (8.8) | 25.9 (5.0) | |
| n < LLN | 3 | 1 | 1 | ||
| Adj. VA | 25.1 (5.7) | 26.5 (10.0) | 25.6 (5.5) | ||
| % pred | 104 (15) | 106 (21) | 105 (13) | ||
| Peak | VO2 | % pred | 106 (25)† | 107 (25) | 129 (25) |
| n < LLN | 3 | 1 | 0 | ||
| ml/kg/min | 32 (9)† | 35 (10) | 40 (9) | ||
| VE | % pred | 123 (30) | 121 (24) | 133 (32) | |
| RER | ratio | 1.21 (0.07) | 1.21 (0.07) | 1.22 (0.06) | |
| HR | bpm | 175 (14) | 179 (8) | 178 (13) | |
| % pred | 102 (9) | 102 (5) | 104 (6) | ||
| RPE | Legs | 8 (2) | 9 (2) | 9 (1) | |
| Dyspnea | 7 (2) | 8 (2) | 8 (2) | ||
| SpO2 | %, at peak | 96 (3) | 95 (3) | 96 (3) | |
| BP | Systolic, mmHg | 153 (18) | 155 (10) | 159 (22) | |
| Diastolic, mmHg | 72 (10) | 71 (10) | 74 (11) | ||
| Hb | g/dl, at peak | 14.8 (1.5) | 15.2 (1.7) | 15.4 (1.4) | |
| Sub-max | Multiple FIO2-DLCO | VCap at 40w, ml | 81 (27) | 83 (38) | 69 (12) |
| VCap adj. VA, ml | 76 (17) | 80 (33) | 69 (12) | ||
| DM, ml/min/mmHg | 76 (38) | 87 (49) | 82 (29) | ||
| Highest Equiv. Work Rate | Power (w) | 80 | 80 | 80 | |
| VE (L/min) | 39 (8)† | 36 (6) | 34 (5) | ||
| IRV (%TLC) | 22 (8) | 22 (4) | 25 (7) | ||
| Dyspnea (Borg) | 3 (1) | 2 (1) | 2 (1) | ||
FVC, forced vital capacity; FEV1, forced expiratory volume in one second; IC, inspiratory capacity; TLC, total lung capacity; RV, residual volume; VO2, oxygen uptake; VE, minute ventilation; RER, respiratory exchange ratio; HR, heart rate; RPE, modified Borg (0–10) rating of perceived exertion; SpO2, arterial oxygen saturation; BP, blood pressure; Hb, hemoglobin; LLN, lower limit of normal; FIO2-DLCO, multiple fraction of inspired oxygen diffusing capacity for carbon monoxide; VA, alveolar volume; VCap, pulmonary capillary blood volume; DM, diffusing membrane capacity; IRV, inspiratory reserve volume. †: p < 0.05 vs. Con; ‡: p < 0.05 vs. ns-CoV.