Table 1.
Baseline characteristics.
| Characteristics | Population | LDK | ETKAS | ESP | P‐value LDK vs. ETKAS vs. ESP | P‐value LDK vs. ETKAS | P‐value LDK vs. ESP | P‐value ETKAS vs. ESP |
|---|---|---|---|---|---|---|---|---|
| N (%) | 348 (100%) | 109 (31.3%) | 100 (28.7%) | 139 (40.0%) | ||||
| Donor age, years | 65.0 [53.0–68.0] | 64.0 [47.5–68.0] | 52.0 [43.0–58.0] | 68.0 [66.0–70.0] | <0.001* | <0.001* | <0.001* | <0.001* |
| Donor sex, male (%) | 171 (49.1%) | 45 (41.3%) | 56 (56.0%) | 70 (50.4%) | 0.097 | 0.033* | 0.155 | 0.389 |
| Deceased donor type DBD (%) | – | – | 53 (53.0%) | 79 (56.8%) | – | – | – | 0.556 |
| Donor cause of death (%) | – | – | – | – | – | 0.522 | ||
| Trauma | – | – | 17 (17.0%) | 19 (13.7%) | ||||
| Cerebrovascular accident or intracranial hemorrhage | – | – | 46 (46.0%) | 72 (51.8%) | ||||
| Circulational | – | – | 1 (1.0%) | 0 (0.0%) | ||||
| Not otherwise specified | – | – | ||||||
| Cold ischemia time, hours | 10 [2–14] | 2 [2–2] | 13.5 [10–17] | 12 [10–15] | <0.001* | <0.001* | <0.001* | 0.062 |
| Total HLA mismatches | 3 [2–5] | 3 [2–4] | 2 [1–3] | 4.5 [3–5] | <0.001* | <0.001* | <0.001* | <0.001* |
| PRA at transplantation (%) | 0.224 | 0.252 | 0.464 | 0.111 | ||||
| 0 | 317 (91.1%) | 101 (92.7%) | 86 (86.0%) | 130 (93.5%) | ||||
| ≤5% | 16 (4.6%) | 3 (2.8%) | 7 (7.0%) | 6 (4.3%) | ||||
| >5% | 15 (4.3%) | 5 (4.6%) | 7 (7.0%) | 3 (2.2%) | ||||
| First transplant | 338 (97.1%) | 107 (98.2%) | 92 (92%) | 139 (100%) | 0.001* | 0.037* | 0.109 | 0.001* |
| Recipient sex, male (%) | 217 (62.5%) | 62 (56.9%) | 64 (64.0%) | 91 (65.9%) | 0.323 | 0.293 | 0.145 | 0.756 |
| Recipient age, years | 68 [66–70] | 68 [66–70] | 68 [66–70] | 68 [66–71] | 0.798 | 0.792 | 0.690 | 0.511 |
| BMI | 26.9 ± 4.0 | 29.9 ± 4.1 | 26.6 ± 3.6 | 27.1 ± 4.3 | 0.577 | 0.549 | 0.641 | 0.277 |
| Primary diagnosis | 0.017* | 0.203 | 0.251 | 0.449 | ||||
| Unknown | 94 (27.2%) | 20 (18.5%) | 31 (31.0%) | 43 (31.2%) | ||||
| Glomerulonephritis | 59 (17.1%) | 17 (15.7%) | 16 (16.0%) | 26 (18.8%) | ||||
| Interstitial nephritis | 19 (5.5%) | 6 (5.6%) | 9 (9.0%) | 4 (2.9%) | ||||
| Cystic kidney disease | 49 (14.2%) | 18 (16.7%) | 11 (11.0%) | 20 (14.5%) | ||||
| Other congenital and hereditary kidney disease | 2 (0.6%) | 1 (0.9%) | 1 (1.0%) | 0 (0.0%) | ||||
| Renal vascular disease | 70 (20.2%) | 26 (24.1%) | 16 (16.0%) | 28 (20.3%) | ||||
| Diabetes Mellitus | 35 (10.1%) | 10 (9.3%) | 13 (13.0%) | 12 (8.7%) | ||||
| Other multisystem diseases | 11 (3.2%) | 6 (5.6%) | 2 (2.0%) | 3 (2.2%) | ||||
| Other | 7 (2.0%) | 4 (3.7%) | 1 (1.0%) | 2 (1.4%) | ||||
| Preemptive transplant | 94 (27%) | 65 (59.6%) | 11 (11.0%) | 18 (12.9%) | <0.001* | <0.001* | <0.001* | 0.649 |
| Dialysis vintage, years † | 2.8 [1.8–4.2] | 1.5 [0.6–2.1] | 3.6 [1.8–5.1] | 2.9 [2.2–4.2] | <0.001* | <0.001* | <0.001* | 0.134 |
| <Median ‡ | 127 (36.5%) | 38 (34.9%) | 33 (33.0%) | 56 (40.3%) | ||||
| CCI | 0.642 | 0.461 | 0.519 | 0.626 | ||||
| 2 | 159 (45.7%) | 55 (50.5%) | 44 (44.0%) | 60 (43.2%) | ||||
| 3–4 | 150 (43.1%) | 42 (38.5%) | 47 (47.0%) | 61 (43.9%) | ||||
| 5+ | 39 (11.2%) | 12 (11.0%) | 9 (9.0%) | 18 (12.9%) |
*
Statistically significant difference.
†
Excluding preemptive transplantation.
‡
n (%) on dialysis shorter than population median dialysis duration (2.8 years).