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[Preprint]. 2023 Jun 16:2022.01.28.477987. [Version 3] doi: 10.1101/2022.01.28.477987

Fig. 5. Antigenic maps including laboratory-made mutants with substitutions at positions 417, 452, 484, and 501.

Fig. 5

A) Variants with substitutions N501Y, E484K, E484Q, and L452R+E484K in the background of D614G; D614G+L452R is not shown since it was titrated against only D614G sera, so its position could not be determined. B) Variants with the T/N417K substitution in the background of P.1 and B.1.351 respectively, and K417N in the background of B.1.429 and B.1.617.1. C) BA.1 with the substitution A484K. The map in panel C is in 3D to highlight the antigenic differences between BA.1, BA.1+A484K, and BA.4/BA.5. The 2D version of panel C is shown in fig. S29. Arrows point from the antigenic position of the root virus to that of the laboratorygenerated variant. Interactive versions of the maps shown in each panel are available online at https://acorg.github.io/mapping_SARS-CoV-2_antigenic_relationships_and_serological_responses.