TABLE 2.

Characteristics of the candidemic episodes

	Period 1 (2004‐2006) n = 68	Period 2 (2014‐2017) n = 102	p‐value
Primary site of infection
Primary bloodstream or intravascular catheter infection	48 (71)	68 (67)	.62
Abdominal	13 (19)	19 (19)	1.00
Other	7 (10)	15 (15)	.49
Candida species
C albicans	39 (57)	56 (55)	.87
C glabrata	14 (21)	30 (29)	.21
C tropicalis	7 (10)	6 (6)	.38
C parapsilosis	2 (3)	4 (4)	1.00
C krusei	1 (1)	3 (3)	.65
Other Candida spp. a	3 (5)	2 (2)	.40
More than one species b	2 (3)	1 (1)	.56
Characteristics at presentation
Timing from hospital admission to candidemia, days	12 (5‐22)	15 (7‐32)	.20
Timing from blood culture sampling to positivity, days	1 (1‐3)	1 (1‐3)	.47
ICU stay at the time of candidemia	13 (19)	39 (38)	.01
Sepsis at diagnosis c	48 (71)	80 (78)	.28
Septic shock at diagnosis c	5 (7)	23 (23)	.01
Bacterial co‐infections during hospital stay	40 (59)	80 (78)	.01

Numbers are total number (percentage) for proportions or median (interquartile range) for continuous variables. Significant p‐value (≤0.05) are in bold characters.

Abbreviations: CVC: central venous catheter; ICU: intensive care unit.

^a Candida pelliculosa (2), Candida kefyr (2), Candida norvegensis (1).

^b C albicans and C glabrata.

^c Sepsis and septic shock were defined according to consensus of the American College of Chest Physicians/Society of Critical Care Medicine (ACCP / SCCM). ¹⁴