FIGURE 8.

The position of known and potential drug target genes on superscaffolds. Different colours indicate different known drugs, and black indicates potential drug targets. The chemical structural formulas of 23 known drugs are drawn. The circles following the potential drug targets represent the six criteria, with a red solid circle indicating match condition and a hollow circle indicating mismatch condition. The six criteria were: (1) Similarity with ChEMBL known drug targets having a highly conserved alignment (>80%). (2) Lack of human homologues. (3) Related to lethal, L3 arrest, flaccid, molt defect or sterile phenotype. (4) A predicted metabolic chokepoint. (5) A predicted excretory/secretory protein (EP). (6) The protein has a structure in the PDBe. Potential drug target proteins encoding genes on each superscaffold and corresponding scores are marked (black)