Figure 6.

A) BGC operon iso1–9 and proposed biosynthetic route leading to the different myxofacyclines (B–D). Proposed reactions catalyzed by module 3 and further tailoring enzymes leading to the heterocycles found in the different myxofacyclines. B) Formation of the isoxazole ring in 1–4, C) hydroxylated 1,2‐dihydropyrrol‐3‐one ring formation in (7) and D) biosynthesis of the 4‐pyrimidinole ring. E) Proposed mechanism of the Beckmann rearrangement during the biosynthesis of 5 and 6.The catalytic domains for each biosynthetic step are colored in blue.