Table 1.
Cytotoxicity of peptides toward human cell lines. Cultures from different cell lines were incubated with various peptide concentrations ranging from 0.01 to 100 µm, for 24 h. Percentage of cell viability was detected using the CellTiter®‐Blue assay.
| IC50 (µm) | ||||||
|---|---|---|---|---|---|---|
| MDA‐MB‐231 | BT‐20 | BT‐474 | SKBR3 | MCF 10A | Hs68 | |
| vCPP0275 | > 100 | 44.8 ± 1.1 | > 100 | 34.0 ± 1.0 | > 100 | > 100 |
| vCPP0417 | > 100 | > 100 | > 100 | > 100 | > 100 | > 100 |
| vCPP0667 | > 100 | 88.8 ± 1.0 | 92.8 ± 1.1 | 71.2 ± 1.1 | > 100 | > 100 |
| vCPP0769 | 9.0 ± 0.1 | 3.5 ± 1.5 | 37.5 ± 1.7 | 21.1 ± 2.0 | 55.4 ± 1.7 | 53.4 ± 0.7 |
| vCPP1779 | > 100 | > 100 | > 100 | > 100 | > 100 | > 100 |
| vCPP2319 | 4.5 ± 0.1 | 4.2 ± 2.2 | 15.7 ± 1.5 | 14.1 ± 1.0 | 16.7 ± 1.3 | 10.8 ± 0.3 |