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. 2021 Nov 1;73(12):2327–2337. doi: 10.1002/art.41887

Figure 5.

Figure 5

Reduction in macrophage YKL‐40 and matrix metalloproteinase 9 (MMP‐9) protein secretion upon small interfering RNA (siRNA)–mediated knockdown of YKL‐40 mRNA. A, YKL‐40 secretion in culture supernatants was reduced by 80–95% after siRNA‐mediated knockdown in macrophages from both patients with giant cell arteritis (GCA) and healthy controls (HCs), left unstimulated or stimulated with lipopolysaccharide (LPS; n = 3 per group). B, MMP‐9 secretion was reduced by 10–50% after siRNA‐mediated knockdown in macrophages from both GCA patients and healthy controls, left unstimulated or stimulated with LPS (n = 3 per group).