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Least squares (LS) mean percentage change in overall Eczema Area and Severity Index (EASI) score from baseline at each timepoint. Week 1: vehicle, n = 81; difamilast 0·3%, n = 83; difamilast 1%, n = 85. Week 2: vehicle, n = 70; difamilast 0·3%, n = 82; difamilast 1%, n = 81. Week 4: vehicle, n = 59; difamilast 0·3%, n = 77; difamilast 1%, n = 77. P‐values are for the comparison between each difamilast group and the vehicle group. *P < 0·001.
