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Least squares (LS) mean change in Verbal Rating Scale (VRS) for pruritus score from baseline at each timepoint. Week 1: vehicle, n = 40; difamilast 0·3%, n = 42; difamilast 1%, n = 43. Week 2: vehicle, n = 37; difamilast 0·3%, n = 42; difamilast 1%, n = 42. Week 4: vehicle, n = 33; difamilast 0·3%, n = 38; difamilast 1%, n = 41. P‐values are for the comparison between each difamilast group and the vehicle group. *P < 0·05; **P < 0·01; ***P < 0·005.
