TABLE 1.

Two recent clinical studies reporting renal metabolic data after ischemia and reperfusion (IR) resulting in acute kidney injury (AKI) or delayed graft function (DGF) ³ , ⁴

Article	Sample timing	IR injury definition	Results on metabolome
Legouis et al. 2020 3	Blood: twice at a 30‐min interval Control group: 4–6 h post‐IR; AKI group: 2–6 days post‐IR	AKI: KDIGO criteria	In patients experiencing AKI: switch from net renal lactate uptake to net renal lactate release, a decrease in net renal glucose release compared to that in the control group
Lindeman et al. 2020 4	Blood: renal artery: 0, 10, and 30 min post‐IR; renal vein: 0.5, 3, 5, 10, 20, and 30 min post‐IR Tissue: postischemia and 45 min post‐IR	DGF: recipient requires dialysis in first week(s) posttransplant, excluding dialysis for hypervolemia, hyperkalemia, or hyperphosphatemia	Grafts manifesting future DGF: postreperfusion ATP/GTP catabolism (significantly impaired phosphocreatine recovery and significant persistent (hypo)xanthine production). Failing high‐energy phosphate recovery occurred despite activated glycolysis, fatty‐acid oxidation, glutaminolysis, and autophagia, and related to a defect at the level of the oxoglutarate dehydrogenase complex in the Krebs cycle