TABLE 4.
An overview of the most commonly used definitions of delayed graft function (DGF) and acute kidney injury (AKI) in clinical practice based on Mallon et al. 40 and Shin et al. 42
| Delayed graft function 40 | |
|---|---|
| Most commonly used | Requirement for dialysis in the first postoperative week |
| Dialysis based | Requirement for dialysis in the first postoperative week excluding the first 24 h |
| Requirement for two or more episodes of dialysis in the first postoperative week | |
| Requirement for dialysis in the first 10 days postoperatively | |
| Functional (creatinine based) | Failure of a fall in serum creatinine of 10% on 3 consecutive days in the first postoperative week |
| Serum creatinine at postoperative day 7 >2.5 mg/dl ( = 221 µM) | |
| Serum creatinine at postoperative day 10 >2.5 mg/dl ( = 221 µM) | |
| Fall in ratio of serum creatinine of postoperative days 1 and 2 of at least 30% | |
| Combination | Dialysis in first week or failure of serum creatinine to fall in first 24 h |
| Dialysis in the first week or serum creatinine at postoperative day 7 >2.5 mg/dl ( = 221 µM) | |
| Acute kidney injury 42 | ||||||
|---|---|---|---|---|---|---|
| RIFLE classification | AKIN classification | KDIGO classification | All | |||
| Serum creatinine | Serum creatinine | Serum creatinine | Urine output | |||
| Risk | ≥1.5 times baseline, or ≥25% decrease in GFR | Stage 1 | ≥0.3 mg/dl (; =; 56.52 µM) increase, or ≥1.5 times baseline within 48 h | Stage 1 | ≥1.5–1.9 times baseline within 7 days, or ≥0.3 mg/dl ( = 56.52 µM) increase within 48 h | <0.5 mL/kg/h for >6 h |
| Injury | ≥2 times baseline, or ≥50% decrease in GFR | Stage 2 | ≥2 times baseline | Stage 2 | ≥2.0–2.9 times baseline within 7 days | <0.5 mL/kg/h for 12 h |
| Failure | ≥3 times baseline, increase to ≥4 mg/dl, or ≥75% decrease in GFR | Stage 3 | ≥3 times baseline, or increase to ≥4.0 mg/dl ( = 353.6 µM) with acute increase of >0.5 mg/dl ( = 44.2 µM), or initiation of RRT | Stage 3 | ≥3 times baseline within 7 days, or increase to ≥4.0 mg/dl ( = 353.6 µM) with acute increase of >0.5 mg/dl ( = 44.2 µM), or initiation of RRT | <0.3 mL/kg/h for 24 h, or anuria for >12 h |
Abbreviations: GFR, glomerular filtration rate; RRT, renal replacement therapy.