TABLE 1.
Characteristics of Participating Survivors and Siblings
| Survivors, No. (%) | Siblings, No. (%) | P a | |
|---|---|---|---|
| Total | 2810 (100) | 1040 (100) | |
| Demographic characteristics | |||
| Age at assessment, median (range), y | 29.67 (11.75‐65.00) | 31.88 (12.42‐73.00) | <.001 |
| <18 y | 294 (10.5) | 62 (6.0) | |
| ≥18 y | 2516 (89.5) | 978 (94.0) | |
| Gender | <.001 | ||
| Male | 1464 (52.1) | 437 (42.0) | |
| Female | 1346 (47.9) | 603 (58.0) | |
| Educational level b | <.001 | ||
| Low | 512 (18.2) | 79 (7.6) | |
| Middle | 1464 (52.1) | 496 (47.7) | |
| High | 801 (28.5) | 458 (44.0) | |
| Employment status c | <.001 | ||
| Employed | 1713 (61.0) | 772 (74.2) | |
| Unemployed | 401 (14.3) | 66 (6.3) | |
| Student | 646 (23.0) | 196 (18.8) | |
| Marital status d | <.001 | ||
| Married or living as married | 1271 (45.2) | 614 (59.0) | |
| Not married | 1457 (51.9) | 339 (32.6) | |
| Divorced or widowed | 52 (1.9) | 21 (2.0) | |
| Health‐related and lifestyle variables | |||
| BMI, median (IQR), kg/m2 e | 23.37 (20.98‐26.04) | 23.51 (21.55‐25.97) | .141 |
| Current smoker f | <.001 | ||
| Yes | 366 (13.0) | 395 (38.0) | |
| No | 2432 (86.5) | 644 (61.9) | |
| Current alcohol use g | <.001 | ||
| Yes | 1183 (42.1) | 518 (49.8) | |
| No | 1623 (57.8) | 521 (50.1) | |
| Drug use in past year h | .002 | ||
| Yes | 262 (9.3) | 118 (11.3) | |
| No | 2506 (89.2) | 919 (88.4) | |
| No. of health problems i | <.001 | ||
| 0 | 1497 (53.3) | 756 (72.7) | |
| 1‐2 | 1069 (38.0) | 228 (21.9) | |
| >2 | 212 (7.5) | 10 (1.0) | |
| Cancer‐ and treatment‐related variables | |||
| Age at diagnosis, median (range), y | 5.42 (0.00‐17.92) | ||
| 0‐4 y | 1069 (38.0) | ||
| 5‐9 y | 992 (35.3) | ||
| 10‐14 y | 574 (20.4) | ||
| 15‐17 y | 175 (6.2) | ||
| Time since diagnosis, median (range), y | 22.42 (11.00‐50.08) | ||
| 10‐19 y | 1150 (40.9) | ||
| 20‐29 y | 956 (34.0) | ||
| ≥30 y | 704 (25.1) | ||
| Diagnosis | |||
| ALL | 837 (29.8) | ||
| Leukemia, not ALL | 125 (4.4) | ||
| Non‐Hodgkin lymphoma | 278 (9.9) | ||
| Hodgkin lymphoma | 186 (6.6) | ||
| CNS tumor | 329 (11.7) | ||
| Neuroblastoma | 158 (5.6) | ||
| Retinoblastoma | 13 (0.5) | ||
| Renal tumor | 314 (11.2) | ||
| Hepatic tumor | 29 (1.0) | ||
| Bone tumor | 163 (5.8) | ||
| Soft tissue and other sarcoma | 198 (7.0) | ||
| Germ cell tumor | 102 (3.6) | ||
| Other and unspecified malignant neoplasm | 78 (2.8) | ||
| Treatment combinations | |||
| Surgery only | 242 (8.6) | ||
| Chemotherapy (± surgery) | 1488 (53.0) | ||
| Radiotherapy (± surgery) | 195 (6.9) | ||
| Chemotherapy and radiotherapy (± surgery) | 876 (31.2) | ||
| No surgery, radiotherapy, or chemotherapy or unknown | 9 (0.3) | ||
| Recurrence | |||
| Yes | 372 (13.2) | ||
| No | 2438 (86.8) | ||
Abbreviations: ALL, acute lymphoblastic leukemia; BMI, body mass index; CNS, central nervous system; IQR, interquartile range.
A t test for continuous variables and a Pearson χ2 test for categorical variables were used.
Missing: 33 survivors (1.2%) and 7 siblings (0.7%). The educational levels were low (up to and including lower technical and vocational education), middle (up to and including secondary technical and vocational education), and high (up to and including higher professional education and university).
Missing: 50 survivors (1.8%) and 6 siblings (0.6%).
Missing: 8 survivors (0.3%) and 5 siblings (0.5%).
Missing: 76 survivors (2.7%) and 17 siblings (1.6%).
Missing: 12 survivors (0.4%) and 1 sibling (0.1%).
Missing: 4 survivors (0.1%) and 1 sibling (0.1%).
Missing: 42 survivors (1.5%) and 3 siblings (0.3%).
Missing: 32 survivors (1.1%) and 46 siblings (4.4%). A description of the assessment of health problems is provided in Supporting Table 1.