TABLE 2.
Multivariable Analysis Assessing Differences in the Prevalence of Chronic Fatigue Between Survivors and Siblings
| OR (95% CI) | P | |
|---|---|---|
| Cohort | ||
| Siblings (reference) | 1.0 | |
| Survivors | 2.194 (1.75‐2.76) | <.001 |
| Gender | ||
| Male (reference) | 1.0 | |
| Female | 2.000 (1.68‐2.38) | <.001 |
| Age at assessment (years) | ||
| <18 y (reference) | 1.0 | |
| 18‐29 y | 1.788 (1.10‐2.90) | .018 |
| 30‐39 y | 1.905 (1.13‐3.21) | .015 |
| ≥40 y | 1.666 (0.98‐2.84) | .060 |
| No. of health problems | ||
| 0 (reference) | 1.0 | |
| 1‐2 | 1.481 (1.23‐1.78) | <.001 |
| >2 | 2.246 (1.62‐3.11) | <.001 |
| Educational level | ||
| Low (reference) | 1.0 | |
| Middle | 1.178 (0.89‐1.56) | .250 |
| High | 1.293 (0.95‐1.76) | .105 |
| Employment status | ||
| Employed (reference) | 1.0 | |
| Student | 0.768 (0.57‐1.04) | .086 |
| Unemployed | 2.061 (1.63‐2.61) | <.001 |
| Current smoker | ||
| No (reference) | 1.0 | |
| Yes | 1.304 (1.04‐1.63) | .020 |
| Current alcohol use | ||
| No (reference) | 1.0 | |
| Yes | 0.697 (0.58‐0.83) | <.001 |
| Drug use in past year | ||
| No (reference) | 1.0 | |
| Yes | 1.114 (0.82‐1.51) | .488 |
| Marital status | ||
| Married or living as married (reference) | 1.0 | |
| Not married | 0.959 (0.78‐1.17) | .681 |
| Divorced/widowed | 1.144 (0.66‐1.98) | .631 |
Abbreviations: CI, confidence interval; OR, odds ratio.
Multivariable logistic regression analyses were used to compare the prevalence of chronic fatigue between childhood cancer survivors and sibling controls; adjustments were made for gender, age at assessment, number of health problems, educational level, employment status, smoking, alcohol consumption, drug use, and marital status. Chronic fatigue was the dependent variable.