Table 2.
Factors Affecting Bone Loss During the 25‐Year Follow‐Up According to 25‐Year Annual Bone Loss Rate Quartiles
| Factor | FQ1 (n = 171) | FQ2 (n = 172) | FQ3 (n = 172) | FQ4 (n = 171) | All (n = 686) | Significance |
|---|---|---|---|---|---|---|
| Age, baseline (years) | 52.9 | 52.5 | 52.5 | 52.7 | 53.4 | p = 0.55 |
| Baseline BMI (kg/m2) | 26.7 | 25.9 | 25.5 | 24.9 | 26.5 | p < 0.001 |
| Postmenopausal at baseline (%) | 58.2 | 52.0 | 60.9 | 58.0 | 62.1 | p = 0.63 |
| Any use of alcohol at baseline (%) | 36.3 | 41.9 | 45.9 | 46.2 | 42.6 | p = 0.21 |
| Smoking, at baseline (%) | 23.4 | 18.0 | 20.9 | 21.6 | 21.0 | p = 0.67 |
| Calcium or vitamin D supplement (%) | 7.0 | 9.3 | 12.2 | 13.5 | 10.5 | p = 0.20 |
| Rheumatoid arthritis, at baseline (%) | 1.2 | 0.6 | 3.5 | 3.5 | 2.2 | p = 0.13 |
| BMI 25 years change (kg/m2) | 1.10 | 2.33 | 2.76 | 3.37 | 2.35 | p < 0.001 |
| HRT use (%) | 26.3 | 32.0 | 35.5 | 41.5 | 23.8 | p = 0.002 |
| Number of chronic diseases (mean) | 7.2 | 7.0 | 6.5 | 7.1 | 4.7 | p = 0.41 |
| Bone‐affecting diseases (%) | 61.4 | 58.1 | 59.3 | 55.0 | 58.9 | p = 0.28 |
| Corticosteroid use (%) | 19.3 | 15.1 | 15.1 | 15.8 | 19.5 | p = 0.41 |
Significance between the quartiles: chi‐square analysis and ANOVA.
ANOVA = analysis of variance.