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. 2021 Nov 25;18(7):1673–1693. doi: 10.1080/15548627.2021.1997051

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Figure 10. — LYG-202 inhibited NLRP3 inflammasome-dependent sterile inflammation and fulminant hepatitis. (A-C) Alum-induced peritoneal infiltration of PEC (A), neutrophils (ITGAM/CD11b⁺ LY6G⁺ ADGRE1/F4/80⁻) (B), and monocytes (ITGAM/CD11b⁺ LY6C⁺ LY6G⁻) (C) in mice 16 h after alum or PBS injection. (D) Peritoneal IL1B in mice 16 h after alum or PBS injection. (E) Immunoblot analysis of CASP1 activation in PECs 16 h after alum or PBS injection. (F) Serum concentrations of GPT/ALT in mice after LPS plus D-gal challenge. (G) Representative liver histology in mice after LPS plus D-gal challenge. (H) Fluorescent staining of ADGRE1/F4/80, Cleaved CASP1, and DAPI in livers of mice after LPS plus D-gal challenge. Data are presented as mean ± SD (n = 6). **P < 0.01.