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. 2021 Dec 29;18(7):1551–1571. doi: 10.1080/15548627.2021.1990670

Figure 7.

Figure 7.

Blocking CMA, but not endosomal microautophagy, rescues the effects of copanlisib on ACLY and ACSS2 abundance. (A) Western blots for indicated proteins in lysates from NIH3T3 cells, that were treated with copanlisib for 48 h, starting 72 h after transfection with negative control (NC) or Lamp2a siRNAs. (B) Quantification of westerns shown in (A). (C) Western blots for indicated proteins in lysates from NIH3T3 cells, that were treated with copanlisib for 48 h, starting 72 h after transfection with negative control (NC) or Tsg101 siRNAs. (D) Quantification of westerns shown in (C). Black bars indicate means and SEM. p values shown on graphs are derived by unpaired t-tests. Significant p-values are replaced with asterisks to save space: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.