Table 3.

IC₅₀ values (μg·mL⁻¹) of the extracts from different sources of fruits of Cm and Ca for the inhibition of pancreatic lipase and α-amylase.

Pancreatic lipase IC50 ± SD [μg·mL−1]
Dried fruit	Cm	CmDN	CmEH	Ca
Aqueous extract	34.2 ± 4.2a	112 ± 18.0*	61.4 ± 4.3 a–d	22.6 ± 3.0c
Ethanolic extract	15.2 ± 3.9b	57.7 ± 8.6a–c	59.0 ± 9.6a–d	25.3 ± 2.0d
Methanolic extract	48.3 ± 12a,b	n.d.	n.d.	13.4 ± 3.6a
Orlistat		2.6 ± 0.5 nM (1.3 ± 0.3 ng·mL−1)
α-Amylase IC50 ± SD [μg·mL−1]
Dried fruit	Cm	CmDN	CmEH	Ca
Aqueous extract	134 ± 6.4†	n.a.	n.a.	136 ± 13.1†
Ethanolic extract	92.5 ± 16.6	n.a.	n.a.	110 ± 5.6†
Methanolic extract	79.0 ± 0.1	n.d.	n.d.	112 ± 2.3†
Acarbose		3.7 ± 0.6 μM (2.4 ± 0.4 μg·mL−1)

Cm – Cornus mas picked fresh, CmDN – Cornus mas Dary Natury, CmEH – Cornus mas Eko Herba, Ca – Cornus alba picked fresh; n.a. – not active (IC₅₀ > 200 μg·mL⁻¹), n.d. – not determined.

Statistical differences between PL IC₅₀ values of extracts are labeled with the same letter a–d (P < 0.05):

^aP < 0.05 vs. Ca methanolic extract;

^bP < 0.05 vs. Cm ethanolic extract,

^cP < 0.05 vs. Ca aqueous extract,

^dP < 0.05 vs. Ca ethanolic extract;

^*P < 0.05 vs. all extracts (pancreatic lipase). Statistical differences between a-amylase IC₅₀ values:

^†P < 0.05 vs. Cm methanolic extract.