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. 2018 May 26;27(1):231–239. doi: 10.1016/j.jfda.2018.05.001

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© 2019 Taiwan Food and Drug Administration

This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — In vivo cytotoxicity evaluation of bioactive compounds. (A) Percentage tumor cell after treatment with samples. The ethyl iso-allocholate at the dose of 30 μg showed maximum growth inhibitory effect, equivalent to doxorubicin (positive control) i.e. 80 ± 5. (B) Percentage liver metastasis. The ethyl iso-allocholate and petroleum ether fraction showed least percentage liver metastasis i.e. 55 ± 3 and 50 ± 3, respectively. (C) Percentage neo-vascularization. The ethyl iso-allocholate treated group showed significantly less formation of new blood vessels (**P < 0.01) i.e. 5 ± 0.8 as compared to the negative control group which was 60 ± 2. (D) All the compounds showed zero percent mortality except ethyl acetate and petroleum ether fraction. dox refers to doxorubicin, compound 3 is benzenepropanoic acid, 3,5-bis (1,1-dimethylethyl)-4-hydroxy, methyl ester and compound 6 is ethyl iso-allocholate.