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The illustration of inflammation-mediated gene regulation through NF-κB and nuclear receptor pathways under disease conditions. CAR: constitutive androstane receptor; IKK: IκB kinase; IL-1β: interleukin-1β; IL-6: interleukin-6; LPS: lipopolysaccharide; LXR: liver X receptor; NF-κB: nuclear factor-κB; NRs: nuclear receptors; PXR: pregnane X receptor; RXR: retinoid X receptor; TLR4: toll-like receptor 4; TNF-α: tumor necrosis factor-α.
