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Effect of AE on the safety evaluation. Serum of the experimental animals was collected. Safety markers were then analyzed respectively. (A) CPK (B) ketone bodies. Data are presented as mean ± SD (n = 8 per group) and analyzed with ANOVA. #p < 0.05, ##p < 0.01, ###p < 0.001 compared with the control. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the HFD + STZ group.
