Comparison 2. General anaesthesia versus non‐general anaesthesia (long‐term time point).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Functional outcome (dichotomous; mRS ≤ 2)	4	625	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.93, 1.58]
2.2 Functional outcome (dichotomous; mRS ≤ 2; only low risk trials)	1	150	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.16, 3.56]
2.3 Functional outcome (continuous; mRS)	7	978	Mean Difference (IV, Random, 95% CI)	‐0.14 [‐0.34, 0.06]
2.4 Functional outcome (continuous; mRS; only low risk trials)	2	278	Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.44, 0.30]
2.5 Stroke‐related mortality	6	843	Risk Ratio (M‐H, Random, 95% CI)	0.88 [0.64, 1.22]
2.6 Stroke‐related mortality (only low‐risk trials)	2	278	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.54, 1.44]