DRKS00023679.

Study name	Anaesthesiological care for thrombectomy in stroke
Methods	Setting: multicentre, Germany Design: RCT, 2 arms, parallel assignment, blind Start date: 6 April 2021
Participants	868 men and women aged ≥ 18 years Inclusion criteria AIS due to arterial occlusion in the anterior cerebral circulation (i.e. ICA or MCA or anterior cerebral artery, or a combination of these), decision for endovascular thrombectomy Exclusion criteria Mandatory GA or endotracheal intubation (e.g. due to airway obstruction that cannot be controlled with naso‐ or oropharyngeal tubes, vomiting with risk of tracheobronchial aspiration, severe agitation corresponding to Richmond Agitation Sedation Scale +3 or +4) Suspected difficult airway Haemodynamic instability (present or expected)  Mild neurological deficit (NIHSS < 5) Prestroke mRS ≥ 3 In‐hospital onset of stroke  Isolated extracranial arterial occlusion Suspected procedural technical difficulties while reaching the target occlusion  Inclusion in another interventional study Age < 18 years
Interventions	Experimental: GA  Comparator: sedation anaesthesia
Outcomes	Primary outcome Proportion of participants able to live independently after 90 days (corresponding to mRS 0–2) Secondary outcome Functional outcome at 30 and 90 days using the complete ordinal mRS Mortality at 90 days Extent of reperfusion after EVT (as graded by the interventionalist using an ordinal score) Final infarct size (derived from study‐specific MRI or routine CT) Neurological symptoms (NIHSS) at 7 days (or discharge) Time from start of anaesthesia to puncture for arterial sheath placement  Time from arterial puncture to reperfusion (or, in the case of unsuccessful efforts, to the last attempt) Frequency of change from sedation to GA: proportion of participants initially awake or under sedation but subsequently intubated
Starting date	6 April 2021
Contact information	Mr Dr med Andreas Ranft, Klinikum rechts der Isar der TU München, Ismaninger Str 22, 81675, München, Germany Telephone: 089 4140 9632; Fax: 089 4140 4886; E‐mail: andreas.ranft at mri.tum.de; URL: www.med.tu-muenchen.de
Notes	DRKS00023679