| Study name |
Choice of anaesthesia for endovascular treatment of acute ischaemic stroke at posterior circulation (CANVAS II): protocol for an exploratory randomised controlled study |
| Methods |
Setting: single‐centre, China
Design: RCT, 2 arms, parallel assignment, open‐label single‐blind
Start date: 15 October 2017
Completion date: 31 March 2021 |
| Participants |
88 men and women aged 18–85 years
Inclusion criteria
With AIS in posterior cerebral circulation scheduled to receive emergency EVT Vertebral artery or basilar artery (or both) responsible for posterior circulation ischaemia confirmed by CTA/MRA mTICI score ≤ 1 Age ≥ 18 years Stroke onset to treatment time ≤ 24 hours mRS ≤ 2 before onset
Exclusion criteria
Unclear radiological image to identify infarction and vessel occlusion Intracranial haemorrhage, anterior circulation occlusion GCS ≤ 8 NIHSS score < 6 or > 30 pc‐ASPECTS < 6 Pons‐midbrain index ≥ 3 Severe agitation or seizures Loss of airway protective reflexes or vomiting, or both, on admission Intubated before EVT Unconsciousness Known allergy to anaesthetics or analgesics
|
| Interventions |
Experimental: GA
Comparator: local/conscious anaesthesia |
| Outcomes |
Primary outcome
Secondary outcomes
Change in NIHSS, from baseline to 24 hours, 7 days (or at discharge), 30 days and 3 months after randomisation mTICI before and after EVT All‐cause mortality up to 3 months after randomisation Incidence of complications up to 3 months after randomisation Length of stay in hospital and ICU after randomisation Rate of conversion from CSA to GA Work‐flow time, including door‐to‐door, door‐to‐groin puncture, puncture complete, groin puncture to recanalisation and treatment time All adverse events
|
| Starting date |
15 October 2017 |
| Contact information |
Ruquan Han
Beijing Tiantan Hospital, China
8610‐67096660; ruquan.han@gmail.com
|
| Notes |
NCT03317535 |
