Peng 2017.

Study name	Choice of anaesthesia for endovascular treatment of acute ischemic stroke: protocol for a randomised controlled (CANVAS) trial
Methods	Setting: single‐centre, China Design: RCT, 2 arms, parallel assignment, open‐label single‐blind Start date: 5 February 2016 (reported in protocol) Completion date: December 2022 (reported in protocol)
Participants	640 men and women aged ≥ 18 years Inclusion criteria Men and women aged 18 years with AIS who are suitable for emergency EVT, fulfilling all of the following criteria: 6 hours after the onset of stroke Functionally independent prior to stroke with mRS score 2 Symptomatic intracranial occlusion, based on single phase, multiphase or dynamic CTA/MRA or DSA, at ≥ 1 of the following locations: ICA, M1, and M2 segments equivalent affecting 4 50% of MCA territory Neuroradiologists and anaesthesiologists agree to proceed with EVT with GA or LA Exclusion criteria Moribund on admission People who require tracheal intubation for airway protection or were intubated on admission GCS score 8 ASPECTS 6 Current NIHSS score > 30 or < 8 Severe agitation or seizures Loss of airway protective reflexes or vomiting, or both Additional intracerebral haemorrhage on brain imaging Posterior circulation infarction Known allergy to anaesthetics or analgesics
Interventions	Experimental: GA Comparator: LA
Outcomes	Primary outcomes Global disability measured by mRS at 90 days after randomisation. Favourable neurological outcome defined as mRS ≤ 2 Secondary outcomes Change in NIHSS at 24 hours, 7 days (or at discharge), 30 days, and 3 months after randomisation mTICI score before and after EVT Intraprocedural systolic blood pressure, diastolic blood pressure, heart rate, and end‐tidal carbon dioxide at 10‐minute intervals All‐cause mortality up to 3 months after randomisation Incidence of complications up to 3 months after randomisation Length of stay in hospital or ICU after randomisation MOCA and MMSE assessed at 24 hours, 7 days (or at discharge), 30 days, and 3 months after randomisation Rate of delirium as measured by CAM after randomisation
Starting date	5 February 2016
Contact information	Ruquan Han Beijing Tiantan Hospital, China 8610‐67096660; ruquan.han@gmail.com
Notes	NCT02677415

AIS: acute ischaemic stroke; ASPECTS: Alberta Stroke Program Early Computed Tomography Score; CAM: Confusion Assessment Method; CSA: conscious sedation anaesthesia; CT: computed tomography; CTA: computed tomography angiography; DSA: digital subtraction angiography; EVT: endovascular treatment; GA: general anaesthesia; GCS: Glasgow Coma Score; ICA: internal carotid artery; ICU: intensive care unit; LA: local anaesthesia; LVO: large vessel occlusion; MCA: middle cerebral artery; MMSE: Mini‐Mental State Examination; MOCA: Montreal Cognitive Assessment; MRA: magnetic resonance angiography; MRI: magnetic resonance imaging; mRS: modified Rankin Scale; mTICI: modified treatment in cerebral ischaemia; NIHSS: National Institutes of Health Stroke Scale; pc‐ASPECTS: post‐circulation Alberta Stroke Program Early Computed Tomography Score; RCT: randomised controlled trial; tPA: tissue plasminogen activator.