TABLE 1.
Couples’ characteristics. Data are reported as median (95% confidence interval). [CFTR = cystic fibrosis transmembrane conductance regulator]
| Overall cohort | |
|---|---|
| Number of female partners | 22,013 |
| Female age (years) | 36.4 (28.0–42.0) |
| Female weight (kg) | 70.0 (56.0–103.0) |
| Female body mass index (kg/m2) | 25.3 (20.5–32.7) |
| Number of male partners | 22,013 |
| Male age (years) | 38.9 (30.1–48.8) |
| Male weight (kg) | 61.0 (59.2–90.0) |
| Male body mass index (kg/m2) | 22.6 (18.4–32.0) |
| Infertility causes | |
| Pelvic, n (%) | 784 (3.6%) |
| Endometriosis, n (%) | 1232 (5.6%) |
| Tubal, n (%) | 2133 (9.7%) |
| Immunological, n (%) | 15 (0.1%) |
| Idiopathic, n (%) | 5943 (27%) |
| Advanced maternal age, n (%) | 4014 (18.2%) |
| Previous pregnancies | |
| 1, n (%) | 3206 (14.6%) |
| 2, n (%) | 1295 (5.9%) |
| 3, n (%) | 475 (2.2%) |
| 4, n (%) | 199 (0.9%) |
| >5, n (%) | 92 (0.4%) |
| Previous miscarriages | |
| 1, n (%) | 2859 (13.0%) |
| 2, n (%) | 1019 (4.6%) |
| 3, n (%) | 316 (1.4%) |
| 4, n (%) | 123 (0.6%) |
| >5, n (%) | 51 (0.3%) |
| Previous pre‐term delivery | |
| 1, n (%) | 139 (0.6%) |
| 2, n (%) | 13 (0.1%) |
| Previous delivery | |
| 1, n (%) | 1386 (6.3%) |
| 2, n (%) | 108 (0.5%) |
| 3, n (%) | 29 (0.1%) |
| 4, n (%) | 16 (0.1%) |
| >5, n (%) | 6 (0.1%) |
| Female abnormal karyotype, n (%) | 49 (0.2%) |
| Female CFTR heterozygous mutations, n (%) | 143 (0.6%) |
| Male abnormal karyotype, n (%) | 165 (0.7%) |
| Male CFTR heterozygous mutations, n (%) | 219 (1.0%) |
| Male Y‐chromosome microdeletions, n(%) | 16 (0.1%) |
| Smoking habit | |
| Female, n (%) | 1805 (8.2%) |
| Male, n (%) | 2322 (10.5%) |