Table 4.

Flow process intensification of the synthesis of the Nelarabine analogue at 10 mm scale with in‐line recycle of the sugar donor during 20 cycles.^[a]

Separation of sugar donor in step 1	Separation of sugar donor in step 2	Recovery of products
		Nelarabine analogue	Hypoxantine
84 %	16 %	78 %	92 %
200 mg	38 mg	23 mg	17.4 mg

[a] The biotransformation by the immobilized HePNP in a PBR was performed at 37 °C with R.T. 2 min and a flow‐rate of 0.85 mL min⁻¹. Step 1 refers to the biotransformation in the PBR and the first separation of sugar donor. For steps 2–4, the solution in the inlet was changed depending on the desired process.