Table 2.
Cox proportional hazards regression analyses with different levels of adjustment reporting hazard ratios with 95% confidence intervals for apolipoprotein C‐III (apoC‐III)
| Hazard ratio (95% confidence interval) | p‐value | |||
|---|---|---|---|---|
|
Diabetic kidney disease (DKD) progression Individuals, n = 3085 Events n = 451 (14.6%) | ||||
| Model 1 | 3.80 (3.04–4.74) | <0.001 | ||
| Model 2 | 2.41 (1.88‐3.08) | <0.001 | ||
| Model 3 | 2.04 (1.59–2.64) a | 1.19 (0.90–1.58) b | <0.001 a | 0.21 b |
| Model 4 | 1.43 (1.05–1.94) a | 0.90 (0.66–1.24) b | 0.02 a | 0.53 b |
|
Major adverse cardiac event Individuals, n = 3597 Events, n = 583 (16.2%) | ||||
| Model 1 | 2.49 (2.05–3.03) | <0.001 | ||
| Model 2 | 1.78 (1.43–2.22) | <0.001 | ||
| Model 3 | 1.30 (1.03–1.64) a | 1.31 (1.03–1.65) b | 0.03 a | 0.03 b |
| Model 4 | 1.05 (0.81–1.36) a | 1.06 (0.81–1.38) b | 0.71 a | 0.67 b |
|
Mortality Individuals, n = 3966 Events, n = 653 (16.5%) | ||||
| Model 1 | 3.66 (3.07–4.38) | <0.001 | ||
| Model 2 | 2.59 (2.11–3.18) | <0.001 | ||
| Model 3 | 1.56 (1.26–1.93) a | 1.55 (1.24–1.94) b | <0.001 a | <0.001 b |
| Model 4 | 1.28 (1.01–1.63) a | 1.27 (0.99–1.63) b | 0.04 a | 0.06 b |
Note. Model 1: sex, diabetes duration; Model 2: model 1 + systolic blood pressure, HbA1c, smoking status, LDL‐cholesterol, lipid‐lowering medication; Model 3: model 2 + baseline DKD categorya (left column) or estimated glomerular filtration rateb (right column); Model 4: model 3 + remnant cholesterol.