TABLE 3.
Severity of food reactions in the evaluation and external validation cohorts
| Cohort | oFASS‐3 | oFASS‐5 | nFASS | ||||
|---|---|---|---|---|---|---|---|
| Level | N (%) | Level | N (%) | Min | Max | Median (Q1, Q3) | |
| Evaluation cohort | |||||||
|
EuroPrevall Outpatient clinic cohort N = 8232 |
Mild | 2946 (35.8%) | Grade 1 | 2946 (35.8%) | 1.07 | 1.07 | 1.07 (1.07,1.07) |
| Moderate | 2839 (34.5%) | Grade 2 | 2236 (27.2%) | 2.01 | 2.80 | 2.23 (2.11, 2.66) | |
| Grade 3 | 603 (7.3%) | 3.03 | 3.98 | 3.38 (3.12, 3.44) | |||
| Severe | 2447 (29.7%) | Grade 4 | 1984 (24.1%) | 4.07 | 5.68 | 4.58 (4.39, 5.01) | |
| Grade 5 | 463 (5.6%) | 6.07 | 7.75 | 6.78 (6.46, 7.26) | |||
| External validation cohorts | |||||||
|
NORA N = 2020 |
Mild | 0 | Grade 1 | 0 | – | – | – |
| Moderate | 210 (10.4%) | Grade 2 | 68 (3.36%) | 2.01 | 2.27 | 2.12 (2.09,2.2) | |
| Grade 3 | 142 (7.02%) | 3.04 | 3.74 | 3.12 (3.09,3.16) | |||
| Severe | 1810 (89.6%) | Grade 4 | 905 (44.8%) | 4.08 | 5.68 | 4.69 (4.44,5.27) | |
| Grade 5 | 905 (44.8%) | 6.11 | 7.64 | 6.57 (6.47,7.15) | |||
|
HCSC Infant Cohort N = 129 |
Mild | 15 (11.6%) | Grade 1 | 15 (11.6%) | 1.07 | 1.07 | 1.07 (1.07,1.07) |
| Moderate | 101 (78.3%) | Grade 2 | 66 (51.2%) | 2.07 | 2.74 | 2.65 (2.11,2.68) | |
| Grade 3 | 35 (27.1%) | 3.07 | 3.44 | 3.12 (3.09,3.4) | |||
| Severe | 13 (10.1%) | Grade 4 | 10 (7.75%) | 4.09 | 4.89 | 4.48 (4.42,4.64) | |
| Grade 5 | 3 (2.32%) | 6.2 | 7.35 | 6.78 (6.49,7.06) | |||
|
EuroPrevall general population N = 635 |
Mild | 291 (45.8%) | Grade 1 | 291 (45.8%) | 1.07 | 1.07 | 1.07 (1.07,1.07) |
| Moderate | 196 (30.9%) | Grade 2 | 170 (26.8%) | 2.01 | 2.74 | 2.65 (2.18, 2.67) | |
| Grade 3 | 26 (4.1%) | 3.03 | 3.43 | 3.37 (3.37,3.41) | |||
| Severe | 148 (23.3%) | Grade 4 | 138 (21.7%) | 4.07 | 5.48 | 4.53 (4.24,5.17) | |
| Grade 5 | 10 (1.57%) | 6.11 | 6.8 | 6.75 (6.3,6.76) | |||
|
SAFE N = 385 |
Mild | 230 (59.7%) | Grade 1 | 230(59.7%) | 1.07 | 1.07 | 1.07 (1.07,1.07) |
| Moderate | 120 (31.2%) | Grade 2 | 103 (26.8%) | 2.07 | 2.68 | 2.65 (2.65,2.65) | |
| Grade 3 | 17 (4.41%) | 3.09 | 3.4 | 3.39 (3.39,3.39) | |||
| Severe | 35 (9.09%) | Grade 4 | 34 (8.83%) | 4.26 | 4.79 | 4.54 (4.26,4.54) | |
| Grade 5 | 1 (0.2%) | 6.46 | 6.46 | 6.46 (6.46, 6.46) | |||
|
iFAAM N = 453 |
Mild | 63 (13.9%) | Grade 1 | 63 (13.9%) | 1.07 | 1.07 | 1.07 (1.07,1.07) |
| Moderate | 210 (46.4%) | Grade 2 | 159 (35.1%) | 2.01 | 2.75 | 2.13 (2.11,2.59) | |
| Grade 3 | 51 (11.3%) | 3.04 | 3.96 | 3.13 (3.09,3.38) | |||
| Severe | 180 (39.7%) | Grade 4 | 111 (24.5%) | 4.07 | 5.63 | 4.52 (4.23, 4.69) | |
| Grade 5 | 69 (15.2%) | 6.07 | 7.55 | 6.56 (6.39,6.81) | |||
Abbreviations: Max, maximum; Min, minimum; Q1, first quartile; Q3, third quartile.