FIGURE 6.

Schematic representations of models of LSD‐induced changes in network organisation. (a) Most gene co‐expression modules reorganise toward a less centralised structure, with central hubs losing connections and peripheral nodes acquiring connections. Overall, the number of available paths across the network increases, resulting in increased signalling entropy. In the proposed model, a single dose of psychedelic drug induces a transient increase in signalling entropy that returns to baseline after 7 days (b), while repeated administrations induce a sustained entropy increase even after discontinuation of the drug (c)