TABLE 2.
Parameter estimates values (relative standard error %) of the best joint final model
| Parameter estimates | Relative standard error (%) | Shrinkage (%) | P value Wald test | |
|---|---|---|---|---|
| Fixed effects | ||||
| Longitudinal submodel | ||||
| M0 (g/L) | 17 | 3.33 | 2.9 | |
| β1 ~ ALBN | −1.41 | 15.8 | 2.34E‐10 | |
| β2 ~ B2MG | 0.331 | 17 | 3.88E‐09 | |
| KL (d−1) | 0.00627 | 8.4 | 23.5 | |
| β3 ~ non_IgG | 0.55 | 27.5 | 0.000277 | |
| KDi (L mol−1 d−1) | 0.0138 | 8.73 | 69 | |
| Ri (day−1) | 0.00579 | 14.6 | 61.5 | |
| KDpd (L mol−1 d−1) | 0.188 | 7.36 | 24.1 | |
| Rpd (d−1) | 0.00952 | 10.6 | 34 | |
| Survival submodel | ||||
| Te (d−1) | 459 | 11.9 | ||
| S | 2.33 | 9.75 | ||
| β4 ~ PCYTOMA = Y | 0.858 | 36.3 | 0.00591 | |
| β5 ~ SlopeM | 11.9 | 7.66 | 4.46E‐39 | |
| Interindividual variability standard deviation | ||||
| ω_M0 | 50.5 | 4.73 | ||
| ω _KL | 88.7 | 6.76 | ||
| ω _KDi | 61.9 | 9.7 | ||
| ω _Ri | 105 | 9.76 | ||
| ω _KDpd | 92 | 6.81 | ||
| ω _Rpd | 110 | 9.33 | ||
| Residual variability | ||||
| σ additive (g/L) | 0.411 | 7.23 | ||
| σ proportional (%) | 15 | 3.65 | ||
Abbreviations: ALBN, baseline serum albumin normalized to the upper limit value; B2MG, baseline β2‐microglobulin; M0, serum M‐protein at baseline, PCYTOMA, Y, presence of plasmacytomas.